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Published on: November 1, 2017
Successful chemotherapeutic treatment for metastatic littoral cell angioma: A case report
Kotoe Takayoshi1, Goro Doi, Nobuhiro Tsuruta
1Department of Medicine and Biosystemic Science Department of Anatomic Pathology, Pathological Sciences Department of Surgery and Science Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Rationale:
Metastatic littoral cell angioma (LCA) is extremely rare. No standard therapeutic strategy has been established, and the impact of chemotherapy has not yet been evaluated.
Patient Concerns:
A 61-year-old woman was admitted because of bicytopenia. She had a splenectomy for LCA of the spleen 10 years earlier. Bone marrow aspiration was normal, and a computed tomography (CT) scan showed hepatomegaly with multiple liver tumors.
Diagnoses:
Liver biopsy samples showed macrophage-like cell infiltration in the hepatic sinusoids. Metastatic LCA was diagnosed based on immunohistochemistry, imaging tests, and the clinical course.
Interventions:
Immunosuppressive agents, such as prednisolone and cyclosporine, were ineffective. Next, cytotoxic agents, such as etoposide, paclitaxel, and vincristine, were administered.
Outcomes:
Cytotoxic agents showed a prominent effect against LCA. CT showed improvement of the hepatomegaly, and fluoro-deoxyglucose (FDG) uptake decreased markedly at a follow-up FDG- positron emission tomography (PET) scan.
Lessons:
Chemotherapeutic treatment based on hemophagocytic syndrome or angiosarcoma might have anti-tumor activity against metastatic LCA. Analysis of the molecular characteristics of this tumor is needed to develop better treatment options.
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