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Baculovirus PTP2 Functions as a Pro-Apoptotic Protein

Yue Han1, Stineke van Houte2, Monique M van Oers3

  • 1Laboratory of Virology, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands. yue.han@wur.nl.

Viruses
|April 13, 2018
PubMed
Summary

The Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) protein tyrosine phosphatase 2 (PTP2) induces apoptosis in host cells. Deleting the PTP2 gene reduced viral occlusion body yield, suggesting PTP2 aids virus replication through immune suppression.

Keywords:
LepidopteraSeMNPVSpodoptera exiguaapoptosisbaculoviruscaspase assayhemocytespro-apoptotic effectsprotein tyrosine phosphatase 2

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