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Chronic migraine: A process of dysmodulation and sensitization

Min Su1,2, Shengyuan Yu1

  • 11 Department of Neurology, Chinese PLA General Hospital, Beijing, China.

Molecular Pain
|April 13, 2018
PubMed

Insights

Chronic migraine, a debilitating daily headache, involves brain alterations and trigeminal system sensitization. Understanding its mechanisms and improving treatment options are crucial for patient care.

Area of Science:

  • Neurology
  • Pain Medicine
  • Headache Disorders

Background:

  • Chronic migraine is a prevalent condition causing significant disease burden.
  • Its pathophysiology, distinct from episodic migraine, remains incompletely understood.
  • Risk factors contributing to migraine progression have been identified.

Purpose of the Study:

  • To review the latest data on chronic migraine.
  • To outline clinical features, pathophysiological mechanisms, and management strategies.
  • To provide direction for future research and improve patient care.

Main Methods:

  • Review of recent scientific literature and clinical data.
  • Analysis of structural and functional brain alterations in chronic migraine patients.
  • Examination of biochemical markers and potential therapeutic targets.

Main Results:

  • Chronic migraine involves maladaptation of top-down pain modulation and trigeminal system sensitization.
  • Structural and functional brain changes are evident in chronic migraine sufferers.
  • Specific molecules implicated in chronic migraine pathogenesis have been identified.

Conclusions:

  • Chronic migraine requires further research into its complex mechanisms.
  • Improved understanding can lead to better therapeutic targets and treatment options.
  • Addressing undertreatment and limited therapy options is essential for managing chronic migraine.
Keywords:
Chronic migrainebiomarkercentral sensitizationtop-down modulation

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