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Related Experiment Videos

Chronic fixed drug eruption caused by acetaminophen.

J D Guin1, G F Baker

  • 1Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.

Cutis
|February 1, 1988
PubMed
Summary

A chronic drug eruption mimicking parapsoriasis was diagnosed. Lesions resolved with acetaminophen avoidance and recurred upon re-exposure, showing a wandering pattern.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Fixed drug eruptions (FDEs) are typically acute reactions to medications.
  • Chronic presentations of FDEs are less common and can be diagnostically challenging.

Observation:

  • A patient presented with persistent, stable skin lesions resembling parapsoriasis en plaques for seven months.
  • The lesions completely resolved upon discontinuation of acetaminophen.
  • Recurrence was observed upon re-exposure to acetaminophen, with a distinct pattern of 'wandering' lesions.

Findings:

  • This case highlights a chronic, fixed drug eruption (FDE) mimicking parapsoriasis en plaques.
  • Acetaminophen was identified as the causative agent, confirmed by resolution and characteristic recurrence.
  • The eruption exhibited a 'wandering' pattern upon re-exposure, a feature often associated with acute FDEs.

Implications:

  • This case expands the clinical spectrum of fixed drug eruptions.
  • It underscores the importance of considering drug reactions in the differential diagnosis of chronic dermatoses.
  • Awareness of chronic FDEs and their varied presentations is crucial for accurate diagnosis and management.

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