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Updated: Feb 12, 2026

Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury
Published on: April 18, 2012
Heart Regeneration in Adult Mammals after Myocardial Damage
Baiping Cui1,2, Yufan Zheng1, Lihua Sun1
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University.
Abstract:
Heart regeneration remains a critical question in current basic research and clinical practice. The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult zebrafish and neonatal mice retain a remarkable ability of heart regeneration after damage. Understanding the mechanisms of heart regeneration would be very valuable to help design efficient treatment strategies against myocardial damage and heart failure. While inherent regeneration of the heart occurs after damage with varying efficiency among species, regeneration may also be induced exogenously. In this study, we briefly review the different approaches and current progress in improving heart regeneration.
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