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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Polypoidal Choroidal Vasculopathy Associated with Optic Disc Coloboma.
Yumiko Nakano1, Akiko Miki1, Shigeru Honda1
1Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
Case Reports in Ophthalmology
|April 13, 2018
Summary
This case report details polypoidal choroidal vasculopathy (PCV) in a patient with optic disc coloboma. Combined treatment with aflibercept and photodynamic therapy successfully resolved symptoms and maintained visual acuity.
Area of Science:
- Ophthalmology
- Medical Case Reports
- Choroidal Vasculopathy
Background:
- Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration.
- Optic disc coloboma is a congenital anomaly affecting optic nerve development.
Observation:
- A 50-year-old woman presented with optic disc coloboma and associated retinochoroidal coloboma.
- Imaging revealed subretinal hemorrhage, serous retinal detachment (SRD), choroidal cavitation, and excavation.
- Fluorescein angiography showed leakage, and indocyanine green angiography identified polypoidal lesions, leading to a PCV diagnosis.
Findings:
- PCV was observed originating from choroidal cavitation linked to the optic disc coloboma.
- Treatment involved intravitreal aflibercept followed by photodynamic therapy.
- Complete resolution of SRD and symptom disappearance occurred within one month.
Implications:
- This is the first reported case of PCV associated with optic disc coloboma.
- Choroidal abnormalities in coloboma may predispose to PCV development.
- Combined therapy demonstrated efficacy in managing this rare presentation.
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