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Association Between MicroRNAs Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis in Chinese Individuals

Chen-Xi Li1, Hong Weng2,3, Jun Zheng1

  • 1Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

Frontiers in Aging Neuroscience
|April 13, 2018
PubMed

Insights

This meta-analysis found that the miR-499 A>G polymorphism is associated with an increased risk of ischemic stroke (IS) in Chinese individuals. No significant link was found between other tested microRNA polymorphisms and IS risk.

Area of Science:

  • Genetics
  • Molecular Biology
  • Epidemiology

Background:

  • Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been implicated in ischemic stroke (IS) risk, but findings are inconsistent.
  • This study focuses on specific miRNA SNPs: miR-146a C>G (rs2910164), miR-149 T>C (rs2292832), miR-196a2 T>C (rs11614913), and miR-499 A>G (rs3746444).
  • Investigating these genetic variations is crucial for understanding the molecular basis of IS susceptibility in specific populations.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between four specific miRNA polymorphisms and the risk of ischemic stroke (IS) in Chinese individuals.
  • To clarify the controversial and inconclusive findings from previous studies regarding miRNA SNPs and IS risk.
  • To evaluate the risk under various genetic models for each miRNA polymorphism.

Main Methods:

  • A meta-analysis was performed on studies identified through PubMed and Embase databases.
  • Included were 5 studies with 2,632 IS cases and 3,191 controls.
  • The association between miRNA polymorphisms and IS risk was quantified using odds ratios (ORs) and 95% confidence intervals (95% CIs) across five genetic models.

Main Results:

  • No significant association was found between miR-146a C>G, miR-149 T>C, and miR-196a2 T>C polymorphisms and IS risk in the overall analysis.
  • The miR-499 A>G (rs3746444) polymorphism showed a significant association with increased IS risk under the allele, heterozygous, and dominant models in the Chinese population.
  • Sensitivity analyses confirmed the overall findings, indicating robustness of the results.

Conclusions:

  • The G allele and AG, AG + AA genotypes of miR-499 A>G (rs3746444) may serve as risk factors for ischemic stroke in Chinese individuals.
  • No significant association was observed between miR-146a C>G, miR-149 T>C, and miR-196a2 T>C polymorphisms and IS risk.
  • Geographical factors within China might influence these associations, necessitating further research in diverse regions with larger sample sizes.
Keywords:
ischemic strokemeta-analysismiR-146amiR-149miR-196a2miR-499polymorphismrisk

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