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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

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Emerging Therapies in Metastatic Prostate Cancer

Daniel W Sonnenburg1, Alicia K Morgans2

  • 1Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology and Robert H. Lurie Comprehensive Cancer Center, 676 N. St. Clair St., Chicago, IL, 60611, USA.

Current Oncology Reports
|April 13, 2018
PubMed
Abstract

Insights

Recent advances in metastatic prostate cancer treatment include chemotherapy and androgen receptor-directed therapies for hormone-sensitive and castration-resistant stages. Ongoing trials explore novel agents and combinations for improved patient outcomes.

Area of Science:

  • Oncology
  • Urology

Background:

  • Metastatic prostate cancer treatment has seen significant therapeutic advancements in both hormone-sensitive and castration-resistant settings over the past decade.
  • Key areas of progress include chemotherapy, androgen receptor-directed therapy, targeted therapies, and immunotherapy.

Purpose of the Study:

  • To review recent therapeutic progress and ongoing clinical trials for metastatic prostate cancer.
  • To highlight advances in various treatment modalities for advanced prostate cancer.

Main Methods:

  • Review of landmark studies and ongoing clinical trials in metastatic prostate cancer treatment.
  • Analysis of data from studies investigating chemotherapy, hormonal therapies, targeted agents, and immunotherapy.

Main Results:

  • Addition of docetaxel chemotherapy or abiraterone acetate to androgen deprivation therapy improved overall survival in metastatic hormone-sensitive prostate cancer.
  • Olaparib, a PARP inhibitor, showed high response rates and improved survival in metastatic castration-resistant prostate cancer with DNA repair defects.
  • Numerous ongoing trials are evaluating novel hormonal therapies, chemotherapy combinations, targeted small molecules, immunotherapy, and radiopharmaceuticals.

Conclusions:

  • Significant progress continues in the management of metastatic prostate cancer.
  • Ongoing clinical trials are crucial for investigating novel agents and treatment strategies to further improve patient outcomes.
Keywords:
Chemohormonal therapyHormonal therapyImmunotherapyMetastatic castration-resistant prostate CancerMetastatic hormone-sensitive prostate CancerRadiopharmaceuticalsTargeted small moleculesTargeting DNA repair defects

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