Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from...

Area of Science:

• Neuroscience
• Clinical Psychology
• Pediatrics

Background:

• Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder affecting children.
• Cognitive training is explored as a potential intervention to improve cognitive functions in children with ADHD.
• Computer-based cognitive training programs aim to enhance specific cognitive skills relevant to ADHD symptoms.

Purpose of the Study:

• To investigate the efficacy of the computer training program ACTIVATE™ in improving cognitive functions in children with ADHD.
• To assess the impact of ACTIVATE™ on ADHD symptoms, and behavioral and functional outcomes.
• To determine if ACTIVATE™ offers a significant benefit over treatment as usual.

Main Methods:

• A multicenter, randomized, single-blind, controlled trial involving 70 children with ADHD (aged 6-13).
• Participants were randomized to receive either ACTIVATE™ training for 8 weeks plus treatment as usual, or treatment as usual alone.
• Cognitive functions, ADHD symptoms (ADHD-RS), and executive functions (BRIEF) were assessed at 8, 12, and 24 weeks post-intervention.

Main Results:

• No significant improvements were observed in the primary outcome, sustained attention, for the ACTIVATE™ group compared to the control group.
• Secondary outcomes, including parent- and teacher-rated ADHD symptoms and executive functions, also showed no significant differences between groups.
• Statistical analysis indicated no significant beneficial effects of the ACTIVATE™ program on any measured outcome.

Conclusions:

• The computer-based cognitive training program ACTIVATE™ did not demonstrate significant efficacy in improving cognitive functions or ADHD-related outcomes in children.
• The study suggests that ACTIVATE™ may not be an effective intervention for this population based on the current findings.
• The trial was likely underpowered, indicating a need for further research with larger sample sizes to detect potential small to moderate treatment effects.