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Electrophysiologic Toxicity of Chemoradiation
Merna A Armanious1,2, Shreya Mishra1, Michael G Fradley3,4
1Division of Cardiovascular Medicine, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA.
Current Oncology Reports
|April 13, 2018
Summary
Cardio-oncology addresses cardiovascular risks from cancer treatments. Understanding chemotherapy
Area of Science:
- Cardio-oncology
- Cardiovascular complications
- Cancer treatments
Background:
- Growing awareness links cancer treatments to cardiovascular complications.
- Cardio-oncology manages cardiovascular risk in cancer patients and survivors.
- Cardiac arrhythmias are underappreciated cardiotoxicities of cancer therapies due to uncertain mechanisms.
Purpose of the Study:
- To review the link between oncology treatments and cardiovascular complications.
- To highlight the role of cardio-oncology in managing these risks.
- To discuss cardiac arrhythmias as potential adverse effects of cancer treatments.
Main Methods:
- Review of recent findings on cardiotoxicities.
- Analysis of arrhythmogenic mechanisms of chemotherapeutic agents.
- Identification of novel agents with arrhythmogenic properties.
Main Results:
- Chemotherapy can induce arrhythmias through direct electrophysiological effects or indirect cardiac damage.
- Increasing numbers of drugs are associated with arrhythmia development.
- Research is identifying new agents and preventative strategies.
Conclusions:
- A deeper understanding of the pathophysiology of electrophysiological effects is needed.
- Preventative measures, early recognition, and surveillance are crucial.
- Managing arrhythmias in cancer patients requires specialized cardio-oncology care.
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