A2. Vulval intraepithelial neoplasia (VIN)

Area of Science:

• Gynecologic Oncology
• Dermatology
• Infectious Diseases

Background:

• Vulvar Intraepithelial Neoplasia 3 (VIN 3) is recognized as a significant precursor to invasive vulvar cancer.
• High-risk human papillomavirus (HPV) types are the primary causative agents in the development of VIN 3.

Purpose of the Study:

• To summarize the clinical presentation, diagnosis, and management of VIN 3.
• To emphasize the importance of early detection and follow-up for VIN 3 lesions.

Main Methods:

• Review of clinical characteristics and diagnostic criteria for VIN 3.
• Outline of established treatment modalities for VIN 3.
• Highlighting the necessity of long-term patient monitoring.

Main Results:

• VIN 3 lesions can be asymptomatic or manifest with symptoms like itching, burning, or visible vulvar lesions.
• Lesions may appear as single or multiple raised, hyperpigmented areas.
• Biopsy is essential for definitive diagnosis of all vulvar lesions.

Conclusions:

• VIN 3 requires prompt diagnosis through biopsy.
• Treatment options including laser vaporization, excision, and cautery are effective.
• Consistent long-term follow-up is critical for managing VIN 3 and preventing recurrence or progression.