Related Experiment Video
Updated: Feb 12, 2026

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
Published on: March 11, 2018
Reactive oxygen species impact on sperm DNA and its role in male infertility
A D Bui1,2, R Sharma1, R Henkel3
1American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Abstract:
Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility. Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative stress (OS), which in turn can lead to nuclear and mitochondrial DNA damage, telomere shortening, epigenetic alterations and Y chromosomal microdeletions. In this review, we discuss how OS induces DNA damage and the types of DNA damage that can occur. We also briefly touch on the clinical consequences of OS-induced DNA damage.
Related Concept Videos
Infertility in Males
What is a Species?
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Keystone Species
Formation of Species
Sperm Transport
The maturation phase occurs in the epididymis, where sperm...

