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Quinacrine sterilization (QS) experience in the Philippines: a preliminary report
1Department of Obstetrics and Gynecology, College of Medicine, Southwestern University, Cebu City, Cebu, Philippines.
Summary
Quinacrine Sterilization (QS) is a safe and effective nonsurgical method for family planning. This study found no pregnancies and only mild side effects in patients undergoing the procedure.
Area of Science:
- Reproductive Health
- Medical Technology Evaluation
- Clinical Trials
Background:
- The Philippines initiated its first clinical trial of Quinacrine Sterilization (QS) in 2000.
- This study aimed to assess the acceptability, safety, effectiveness, and side effects of QS for family size limitation.
Purpose of the Study:
- To evaluate the safety and effectiveness of Quinacrine Sterilization (QS) as a method of nonsurgical sterilization.
- To assess patient acceptability and side effects associated with the QS procedure.
Main Methods:
- The trial involved 36 female volunteers who underwent transcervical insertion of quinacrine pellets on two occasions, one month apart.
- Informed consent was obtained after a thorough explanation of the procedure. Patients were advised to use condoms for six weeks post-second insertion, unless on other contraceptives.
Main Results:
- The study accumulated 515 woman-months of experience with zero reported pregnancies (intrauterine or ectopic).
- Adverse events were mild, including yellow discharge, itching, and moderate abdominal discomfort in 50% of patients, managed with mefenamic acid.
Conclusions:
- Quinacrine Sterilization (QS) demonstrated safety and effectiveness in this small-scale clinical trial.
- The study supports the continued offering of QS as a viable nonsurgical sterilization option.
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