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Quinacrine sterilization: a retrospective.

J Zipper1, E Kessel2

  • 1Department of Obstetrics and Gynecology, Sótero del Río Hospital, University of Chile, Santiago, Chile.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|April 13, 2018
PubMed
Summary
This summary is machine-generated.

Quinacrine sterilization (QS) offers a safe, inexpensive, non-surgical female sterilization method. Developed to overcome initial absorption issues, the pellet form is over 98% effective after two years.

Keywords:
contraceptionfemale sterilizationquinacrine sterilization

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Pharmacology

Background:

  • High rates of septic abortion in high-parity women necessitated safer sterilization.
  • Early attempts at non-surgical female sterilization faced challenges.

Purpose of the Study:

  • To trace the development of quinacrine sterilization (QS).
  • To evaluate the safety and efficacy of a novel non-surgical female sterilization method.

Main Methods:

  • Review of published reports on quinacrine sterilization development.
  • Initial trials involved transcervical instillation of quinacrine slurry.
  • Subsequent development focused on a slow-dissolving quinacrine pellet delivered transcervically.

Main Results:

  • Early quinacrine slurry method showed efficacy but had safety concerns (cortical excitation, deaths).
  • The modified pellet form, delivered transcervically, demonstrated improved safety and efficacy.
  • The standard protocol using seven 36 mg pellets, administered twice a month apart, achieved over 98% protection at 2 years.

Conclusions:

  • Quinacrine sterilization (QS) is ready for widespread adoption.
  • QS is particularly suitable where surgical sterilization is unsafe, unavailable, or undesirable due to patient factors.