Hypercalcemia in a bodybuilder with cosmetic silicone injections

Area of Science:

• Endocrinology
• Dermatology
• Nephrology

Background:

• Silicone injections are increasingly used for body contouring.
• Granulomatous hypercalcemia is a rare complication associated with silicone.
• Literature on this specific condition is scarce.

Observation:

• A 35-year-old male bodybuilder presented with hypercalcemia and urinary symptoms after multiple silicone injections in his upper extremities.
• The patient required two sessions of dialysis due to the severity of his condition.
• A biopsy of the affected upper arm revealed granulomatous tissue.

Findings:

• The case confirms a link between silicone injections and granulomatous hypercalcemia.
• Corticosteroid therapy was effective in resolving the hypercalcemia and associated symptoms.
• Histopathological examination supported a granulomatous inflammatory response to silicone.

Implications:

• Healthcare providers should consider silicone-induced hypercalcemia in patients with unexplained hypercalcemia and a history of cosmetic injections.
• Increased awareness is necessary due to the rising popularity of body enhancement procedures involving fillers and implants.
• Prompt diagnosis and management, including immunosuppressive therapy, can prevent severe complications like kidney injury.