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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

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Published on: February 20, 2017

Molecular mechanisms of fission in echinoderms: Transcriptome analysis.

Igor Yu Dolmatov^1,2, Sergey V Afanasyev³, Alexey V Boyko^1,2

¹A.V. Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.

|April 13, 2018

Summary

Echinoderms reproduce asexually through body fission, driven by changes in connective tissue strength. This study reveals complex molecular mechanisms underlying this process, offering insights into extracellular matrix mutability and regeneration.

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Area of Science:

Marine Biology
Developmental Biology
Biochemistry

Background:

Echinoderms exhibit asexual reproduction via fission, a process linked to body wall connective tissue changes.
The precise mechanisms governing connective tissue strength variations and its structure in echinoderms are not well understood.

Purpose of the Study:

To investigate the molecular underpinnings of connective tissue mutability during asexual reproduction in holothurians.
To identify key genes and pathways involved in regulating fission and regeneration in echinoderms.

Main Methods:

Transcriptome analysis of the holothurian Cladolabes schmeltzii during fission.
Identification and characterization of genes encoding extracellular matrix proteins, proteases, and inhibitors.

Main Results:

Discovered a complex connective tissue organization in Cladolabes schmeltzii, with numerous genes for structural proteins, proteases, and inhibitors.
Echinoderm extracellular matrix differs from vertebrates, notably lacking elastin, fibronectins, and tenascins.
Identified holothurian tensilins as a unique class of metalloproteinase inhibitors specific to Holothuroidea.

Conclusions:

The identified molecules likely regulate connective tissue mutability and asexual reproduction in echinoderms.
Gene expression patterns suggest involvement of transcription factors and signaling pathways in fission and regeneration.
Findings provide a foundation for further research into echinoderm extracellular matrix dynamics and asexual reproduction.