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Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
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FGF2 Enhances Odontoblast Differentiation by αSMA+ Progenitors In Vivo.

I Vidovic-Zdrilic1, K H Vining2, A Vijaykumar1

  • 11 Departments of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA.

Journal of Dental Research
|April 13, 2018
PubMed
Summary

Fibroblast growth factor 2 (FGF2) promotes the differentiation of dental pulp cells into odontoblasts. This study shows FGF2 enhances reparative dentin formation by stimulating αSMA-expressing progenitor cells.

Keywords:
dentin matrix protein 1 (DMP1)dentin sialophosphoprotein (DSPP)perivascular cellspulp biologyreparative dentinogenesisstem cells

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Area of Science:

  • Cell Biology
  • Regenerative Medicine
  • Dental Research

Background:

  • Dental pulp regeneration is crucial for maintaining tooth vitality.
  • Understanding progenitor cell behavior in response to growth factors is key to developing regenerative therapies.
  • Perivascular cells expressing alpha-smooth muscle actin (αSMA) are potential progenitor cells in dental pulp.

Purpose of the Study:

  • To investigate the in vivo effects of early and limited exposure to fibroblast growth factor 2 (FGF2) on αSMA-expressing perivascular cells.
  • To determine if FGF2 can stimulate reparative dentinogenesis by influencing these progenitor cells.

Main Methods:

  • In vivo fate mapping using inducible Cre-loxP systems.
  • Experimental pulp injury in molars to induce reparative dentinogenesis.
  • Administration of exogenous FGF2 to exposed dental pulp.

Main Results:

  • Early FGF2 delivery led to the proliferative expansion of αSMA-tdTomato+ cells.
  • FGF2 accelerated the differentiation of these cells into odontoblasts.
  • Reparative dentin in FGF2-treated pulps showed an increased number of Dspp+ odontoblasts and lacked BSP+ osteoblasts.

Conclusions:

  • Fibroblast growth factor signaling stimulates odontoblast differentiation from early progenitors in dental pulp.
  • αSMA-expressing cells are a source of odontoblasts involved in FGF2-induced reparative dentin formation.
  • This study provides in vivo evidence for FGF2's role in promoting osteoblast-free reparative dentinogenesis.