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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Inonotolides A-C, isopimarane diterpenoid lactones from Inonotus sinensis
Jian-Hai Ding1, Zheng-Hui Li2, Tao Feng2
1College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, Ningxia 756000, PR China; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, PR China.
Abstract:
Three new isopimarane diterpenoid lactones, named inonotolides A-C (1-3), were isolated from cultures of the basidiomycete Inonotus sinensis. Their structures were elucidated on the basis of extensive spectroscopic studies and the structure of inonotolide A (1) was confirmed by single-crystal X-ray crystallographic analysis. All compounds were evaluated for their cytotoxicities against five human cancer cell lines.
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