Related Experiment Video
Updated: Feb 12, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Diffuse dermatophytosis occurring on dimethyl fumarate therapy
1Multiple Sclerosis Research Institute, Philadelphia, PA, USA.
Background:
Opportunistic infections have occurred during dimethyl fumarate (DMF) therapy.
Objective:
Diffuse skin dermatophytosis which occurred during DMF therapy in the setting of lymphopenia is described.
Methods And Results:
The clinical course, the lymphocyte subset profile, and dermatologic evaluations were reviewed. In both instances, there was no other cause of lymphopenia or immune suppression, and it is likely that the tinea infections are associated with DMF therapy.
Conclusion:
The occurrence of dermatophytosis widens the spectrum of opportunistic infections associated with DMF therapy. Further research is necessary to fully elucidate the mechanism of lymphopenia and potentially impaired immune competence during DMF therapy.
More Related Videos
Related Concept Videos
Diffusion
Diffusion
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps
Errors occurring during blood pressure monitoring
Several factors...
Facilitated Diffusion
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...

