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Updated: Feb 12, 2026

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Diffuse dermatophytosis occurring on dimethyl fumarate therapy.

Jeffrey I Greenstein1

  • 1Multiple Sclerosis Research Institute, Philadelphia, PA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 14, 2018
PubMed
Summary

Diffuse skin infections, known as dermatophytosis, can occur during dimethyl fumarate (DMF) therapy due to associated lymphopenia. This finding expands the known opportunistic infections linked to DMF treatment.

Keywords:
Multiple sclerosisdermatophytosisdimethyl fumarateimmune suppressionlymphopenia

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Dimethyl fumarate (DMF) is a medication used in treating certain conditions.
  • Opportunistic infections have been documented in patients undergoing DMF therapy.

Observation:

  • This report describes cases of diffuse skin dermatophytosis (tinea infections) in patients treated with DMF.
  • These infections occurred in the context of lymphopenia, a reduced lymphocyte count.

Findings:

  • Clinical and laboratory data, including lymphocyte subset profiles, were reviewed.
  • No alternative causes for lymphopenia or immune suppression were identified.
  • The tinea infections are strongly suspected to be associated with DMF therapy.

Implications:

  • The occurrence of dermatophytosis broadens the spectrum of opportunistic infections linked to DMF.
  • Further research is needed to understand the mechanisms behind DMF-induced lymphopenia and immune changes.