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Updated: Feb 12, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Pulmonary paracoccidioidomycosis associated with the use of natalizumab in multiple sclerosis
Kelson James Almeida1, Raissa Viera Barreto-Soares2, Raimundo Nonato Campos-Sousa3
1Department of Neurology, Central Institute, Clínicas Hospital, University of São Paulo, São Paulo, Brazil.
Background:
Natalizumab (NTZ) is a monoclonal antibody with an immunosuppressive effect that reduces the inflammation of the central nervous system, and it has been used for the treatment of relapsing-remitting multiple sclerosis (RRMS). In patients with low cellular immune response, systemic mycosis arising from endemic areas may occur.
Results And Conclusion:
In this article, we will describe a case of paracoccidioidomycosis as a complication to treatment with NTZ in an RRMS patient.
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