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Tocainide: a severe adverse reaction.

J M Dunn1, P E Groth, A DeSimone

  • 1Verex Laboratories, Inc., Englewood, CO 80112.

Drug Intelligence & Clinical Pharmacy
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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Tocainide, an antiarrhythmic drug, caused severe adverse effects including skin eruption and neurological symptoms in a patient. Careful monitoring and cautious use are advised due to its potency and long half-life.

Area of Science:

  • Cardiology
  • Pharmacology
  • Dermatology

Background:

  • Tocainide is an antiarrhythmic medication, structurally similar to lidocaine.
  • It is prescribed for managing ventricular rhythm disorders.

Observation:

  • A 76-year-old male patient experienced severe adverse reactions after initiating tocainide therapy.
  • Symptoms included a widespread skin rash, bleeding gums, vertigo, tremors, fever, and memory loss.

Findings:

  • The patient required hospitalization due to the severity of the adverse effects.
  • Discontinuation of tocainide and supportive care led to a slow, three-month recovery without lasting complications.

Implications:

  • Tocainide is a potent drug with a significant potential for adverse events.

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  • Physicians should exercise caution when prescribing tocainide, considering its long biological half-life and potential side effects.