Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

5.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.1K
Node Analysis for AC Circuits01:14

Node Analysis for AC Circuits

682
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
682
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

23.5K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.5K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

18.6K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
18.6K
The Evidence for Evolution02:55

The Evidence for Evolution

48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Metastasis02:30

Metastasis

6.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of electrosurgery for skin incision and dissection: randomized comparative study in 85 patients.

Actas dermo-sifiliograficas·2026
Same author

Oncologic Safety in Solid Organ Transplant Recipients With a Past Medical History of Early-stage Melanoma: A Retrospective Cohort Study.

Actas dermo-sifiliograficas·2026
Same author

Multicenter Observational Study on Recurrence Patterns and Health Care Resource Utilization in Stage II Cutaneous Melanoma in Spain: Real-world Evidence From the METHEOR Study.

Actas dermo-sifiliograficas·2026
Same author

Complete Lymph Node Dissection vs Observation in Patients With Cutaneous Melanoma and Positive Sentinel Lymph Node Biopsy With High-risk Criteria: Multicenter Analysis in Hospitals in the Mediterranean Area.

Actas dermo-sifiliograficas·2026
Same author

Is Neoadjuvancy with Imatinib Useful Before Mohs Surgery in Locally Advanced Dermatofibrosarcoma Protuberans? Experience of a Dermato-Oncology Referral Center.

International journal of molecular sciences·2026
Same author

Comparison of Histological Resection Margins After Incision With Electrosurgical Scalpel vs Conventional Scalpel in the Excision of Basal Cell Carcinomas.

Actas dermo-sifiliograficas·2026
Same journal

Fingolimod-associated lymphomatoid papulosis.

Actas dermo-sifiliograficas·2026
Same journal

Demodicosis: update and treatment with laser and other light sources.

Actas dermo-sifiliograficas·2026
Same journal

New treatments for adult female acne.

Actas dermo-sifiliograficas·2026
Same journal

First regulations of the Spanish Society of Dermatology (1909).

Actas dermo-sifiliograficas·2026
Same journal

Long-hair FUE: advantages and disadvantages of the most recent technique in hair transplantation.

Actas dermo-sifiliograficas·2026
Same journal

Sunburns, Tanning, and Social Media: A Descriptive Study Among Spanish University Students.

Actas dermo-sifiliograficas·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.5K

Lymph Node Dissection in Patients With Melanoma and Sentinel Lymph Node Metastasis: An Updated, Evidence-Based

D Moreno-Ramírez1, A Boada2, L Ferrándiz3

  • 1Servicio de Dermatología, Hospital Clínic, Barcelona, España.

Actas Dermo-Sifiliograficas
|April 14, 2018
PubMed
Summary
This summary is machine-generated.

Recent clinical trials show lymph node dissection offers no survival benefit for melanoma patients with sentinel node metastasis. Treatment reconsideration is needed, especially for low-risk cases where dissection is not supported.

Keywords:
Adjuvant therapyBiopsia selectiva del ganglio centinelaDisección ganglionarLymph node dissectionMelanomaSentinel lymph node biopsyTratamiento adyuvante

More Related Videos

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.8K
Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.8K

Related Experiment Videos

Last Updated: Feb 12, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.5K
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.8K
Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.8K

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Sentinel node metastasis is a critical prognostic factor in melanoma.
  • Recent clinical trials challenge the necessity of lymph node dissection (LND) in specific patient groups.
  • Evolving evidence necessitates a re-evaluation of melanoma treatment protocols.

Purpose of the Study:

  • To update clinicians on evidence regarding sentinel node-positive melanoma management.
  • To identify key factors influencing treatment decisions for these patients.
  • To propose a decision-making algorithm for managing sentinel node-positive melanoma.

Main Methods:

  • Review of current clinical trial data and evidence.
  • Analysis of factors including metastatic spread, predictors, and adjuvant therapies.
  • Development of a clinical decision-making algorithm.

Main Results:

  • Lymph node dissection (LND) is not associated with survival benefit in patients with sentinel node metastasis.
  • Low-risk sentinel node metastasis (tumor load ≤1mm) does not warrant LND.
  • Several factors, including routes of spread and adjuvant therapy, are crucial for treatment planning.

Conclusions:

  • The current evidence does not support routine lymph node dissection for all patients with sentinel node-positive melanoma.
  • A nuanced approach considering tumor characteristics and patient factors is essential.
  • A proposed algorithm aims to guide clinical decision-making in this setting.