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[Extrauterine growth restriction among neonates with a birthweight less than 1,500grams]

Alejandro Avila-Alvarez1, Alfonso Solar Boga2, Carmen Bermúdez-Hormigo1

  • 1Unidad de Neonatología, Servicio de Pediatría. Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, España; Departamento de Pediatría, Universidade de Santiago de Compostela, Santiago de Compostela, España.

Anales De Pediatria
|April 14, 2018
PubMed

Insights

Postnatal growth restriction affects over half of premature infants under 1,500 grams, primarily during NICU stays. Higher urea levels are linked to poorer weight gain in these vulnerable newborns.

Area of Science:

  • Neonatalogy
  • Pediatric Growth and Development
  • Clinical Biochemistry

Background:

  • Postnatal growth restriction in preterm infants is a significant concern linked to adverse neurodevelopmental outcomes.
  • Understanding the incidence and predictors of growth restriction is crucial for improving infant health.

Purpose of the Study:

  • To determine the incidence of postnatal growth restriction in premature infants weighing ≤1,500 grams at birth.
  • To identify clinical and biochemical markers associated with growth restriction in this population.

Main Methods:

  • A retrospective longitudinal observational study design was employed.
  • Multivariate linear regression models were utilized to identify predictors of weight z-score changes during hospitalization.

Main Results:

  • The study included 130 preterm infants (mean birthweight 1,161±251g, gestational age 29.9±2.5 weeks).
  • At hospital discharge, 59.2% of infants exhibited a weight below the 10th percentile (P10).
  • Weight and length z-scores decreased significantly during NICU admission, with higher urea levels negatively correlating with weight z-score changes.

Conclusions:

  • Over half of preterm infants ≤1,500 grams experience growth restriction, with significant decreases occurring during NICU admission.
  • Lower birth weight (
  • The negative correlation between urea levels and weight gain warrants further investigation into the protein-growth relationship in neonates.
Abstract

Keywords:
Crecimiento posnatalGrowth retardationPostnatal growthPremature infantsRecién nacido de muy bajo pesoRecién nacido prematuroRetraso del crecimientoVery low birth weight infant

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