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Clioquinol, an alternative antimicrobial agent against common pathogenic microbe.

Z You1, X Ran1, Y Dai2

  • 1Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, 610041 Chengdu, Sichuan Province, China.

Journal De Mycologie Medicale
|April 14, 2018
PubMed
Summary

Topical 3% clioquinol cream shows broad-spectrum antifungal activity against common skin pathogens. While its antibacterial effects are weak, it effectively inhibits many fungal species, offering a potential treatment option.

Keywords:
3% clioquinolDrug susceptibilityModified agar diffusion assayTopical pharmaceuticals

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Area of Science:

  • Dermatology
  • Antimicrobial research
  • Mycology

Background:

  • Skin and soft tissue infections (SSTIs) are prevalent, necessitating effective antimicrobial treatments.
  • Increasing drug resistance in pathogens drives the need for novel or repurposed antimicrobial agents.
  • Clioquinol, an antiseptic, has limited data regarding its antimicrobial spectrum and efficacy in infections.

Purpose of the Study:

  • To evaluate the antimicrobial spectrum and activity of topical 3% clioquinol cream.
  • To compare its efficacy against common pathogenic microorganisms with other topical pharmaceuticals.
  • To investigate clioquinol's potential in combating drug-resistant strains.

Main Methods:

  • Modified agar diffusion assay was employed to assess drug susceptibility.
  • Broth microdilution assay was used for comparative analysis.
  • Thirty fungal strains (14 species) and 5 bacterial strains (4 species) were tested.

Main Results:

  • 3% clioquinol cream demonstrated significant inhibition against most tested fungal species.
  • Strongest antifungal activity was observed against Candida tropicalis, Candida guilliermondii, Aspergillus terreus, Fusarium solani, and Trichoderma harzianum.
  • Moderate antifungal activity was noted for Dermatophytes and Candida albicans, while antibacterial activity was weak.
  • Both assay methods showed consistent results.

Conclusions:

  • Topical 3% clioquinol cream possesses a broad antifungal spectrum.
  • Its efficacy varies by species, but it is effective against a wide range of fungi.
  • Clioquinol cream shows promise as a topical antifungal agent, particularly for resistant fungal infections.