Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.0K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

363
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
363
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study Protocol and Characteristics of the Wearable Device Survey for Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.

Journal of epidemiology·2026
Same author

Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization.

Circulation reports·2026
Same author

Association of subjective and objective physical activity with home hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same author

Correction: Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study.

Scientific reports·2026
Same author

Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study.

Molecular psychiatry·2026
Same author

Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.

The Tohoku journal of experimental medicine·2026

Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K

[Human Genome Data and Drug Development].

Soichi Ogishima1

  • 1Dept. of Bioclinical Informatics, Group of Integrated Database Systems, Tohoku Medical Megabank Organization, Tohoku University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 14, 2018
PubMed
Summary
This summary is machine-generated.

Genome-based drug development uses human genome data for new medicines. Medical big data, including genomic and clinical information, is crucial for this advancement and data sharing is increasing.

More Related Videos

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

10.3K
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

17.3K

Related Experiment Videos

Last Updated: Feb 12, 2026

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

10.3K
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

17.3K

Area of Science:

  • Genomic Medicine
  • Drug Discovery
  • Bioinformatics

Background:

  • Human genome data is increasingly vital for pharmaceutical research and development.
  • Medical big data, integrating genomic and clinical information, is an essential resource.
  • The field of genome-based drug development is rapidly evolving.

Purpose of the Study:

  • To review the utilization of human genome data in drug development.
  • To examine the current status of platforms for genomic medicine that collect genome and clinical data.
  • To explore emerging trends in genomic data sharing.

Main Methods:

  • Literature review of studies on genome-based drug development.
  • Analysis of current platforms for collecting and integrating genomic and clinical data.
  • Survey of recent developments in genomic data sharing initiatives.

Main Results:

  • Genome data significantly impacts drug discovery pipelines.
  • Platforms for genomic medicine are developing to integrate diverse datasets.
  • New initiatives are emerging to facilitate secure and efficient genomic data sharing.

Conclusions:

  • Genome-based drug development is a critical area in modern medicine.
  • Integrated genomic and clinical data platforms are essential for advancing personalized medicine.
  • Enhanced genomic data sharing is key to accelerating research and therapeutic innovation.