[Asynchronous Bilateral Neuroendocrine Breast Carcinoma - A Case Report]

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Neuroendocrine breast carcinoma is a rare malignancy.
• Bilateral presentation is exceptionally uncommon.

Observation:

• A 49-year-old woman presented with right breast bloody nipple discharge.
• Initial diagnosis of intraductal papilloma was revised to neuroendocrine carcinoma post-surgery.
• Ten years later, a contralateral neuroendocrine breast carcinoma was detected via ultrasonography.

Findings:

• Both primary tumors were estrogen receptor-positive, progesterone receptor-positive, chromogranin A-positive, and synaptophysin-positive.
• HER2/neu marker was negative in both.
• Ki-67 labeling index was 40% in the right breast and 50% in the left.
• CD56 was positive in the left breast tumor.

Implications:

• This case highlights the importance of considering rare diagnoses like bilateral neuroendocrine breast carcinoma.
• Ultrasonography is a valuable tool for early detection of asynchronous bilateral breast lesions.
• Management involved surgery, radiotherapy, and hormonal therapy, demonstrating a multidisciplinary approach.