Related Experiment Video

Updated: Feb 12, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.6K

Percutaneous Closure of Left Atrial Appendage significantly affects Lipidome Metabolism

G Yücel1,2, M Behnes3, C Barth1

  • 1First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.

Scientific Reports
|April 14, 2018
PubMed

Insights

Left atrial appendage occlusion (LAAC) devices, used for stroke prevention in atrial fibrillation (AF) patients, may alter lipid metabolism. This study found significant changes in 34 lipids six months post-LAAC implantation.

Area of Science:

  • Cardiology
  • Metabolomics
  • Biochemistry

Background:

  • Non-valvular atrial fibrillation (AF) patients at high risk for oral anticoagulation are candidates for left atrial appendage occlusion (LAAC) devices to prevent cardio-embolic stroke.
  • The impact of LAAC on lipid metabolism remains unexplored.

Purpose of the Study:

  • To investigate the potential influence of percutaneous LAAC on lipid metabolism in patients with non-valvular AF.
  • To identify specific lipid alterations following LAAC implantation.

Main Methods:

  • A cohort of patients with successful LAAC implantation was enrolled.
  • Targeted metabolomics using electrospray ionization liquid chromatography-mass spectrometry (ESI-LC-MS/MS) was performed on blood samples collected at baseline and 6 months post-procedure.
  • Multivariable logistic regression models were used to adjust for potential confounding factors.

Main Results:

  • A total of 34 lipids showed significant changes from baseline to 6-month follow-up after LAAC.
  • These alterations persisted after multivariable adjustment for factors including gender, age, diabetes, BMI, LVEF, creatinine, and NT-proBNP.
  • Subgroup analyses indicated potential confounding influences from various patient characteristics.

Conclusions:

  • Percutaneous LAAC may significantly affect lipid metabolism.
  • These metabolic changes could potentially influence pro-atherogenic and cardio-toxic effects, warranting further investigation.

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.2K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.4K

Related Concept Videos

Surface Appendages of Archaea01:23

Surface Appendages of Archaea

Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...
685
What is Metabolism?00:52

What is Metabolism?

Overview
132.4K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.4K
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
38.7K
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.7K