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Updated: Jul 18, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
The evasion of the immune response and immunological unresponsiveness: parasitic helminth infections
1University of Cambridge, Department of Clinical Veterinary Medicine, U.K.
Abstract:
A selective review is given of the mechanisms associated with the evasion of the immune response by parasitic helminths and immunological unresponsiveness as it applies to helminth infections. Immunosuppression caused by parasites leading to reduced responsiveness of lymphocytes to mitogens is discussed, and mechanisms that inhibit effector mechanisms at the parasite surface and polyclonal activation of lymphocyte populations are dealt with. Physiological immunosuppression associated with parturition and lactation and the immunological unresponsiveness of young ruminants are dealt with in detail.
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