Related Experiment Video

Updated: Feb 12, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Delayed vs. immediate stenting in STEMI with a high thrombus burden : A systematic review and meta-analysis

B Sun1, J Liu2, H Yin1

  • 1Department of Cardiology, The Third Hospital of Hebei Medical University, NO.139 Ziqiang Road, Qiaoxi District, 050051, Shijiazhuang, China.

Herz
|April 14, 2018
PubMed

Insights

Delayed stenting (DS) offers improved outcomes for ST-segment elevation myocardial infarction (STEMI) patients with high thrombus burden compared to immediate stenting (IS). DS enhances myocardial reperfusion and reduces major adverse cardiac events without increasing bleeding risk.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Controversy exists regarding delayed stenting (DS) versus immediate stenting (IS) in ST-segment elevation myocardial infarction (STEMI).
  • The specific benefit of DS in STEMI patients with a high thrombus burden requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy and safety of delayed stenting (DS) compared to immediate stenting (IS) in STEMI patients presenting with a high thrombus burden.
  • To assess outcomes related to myocardial reperfusion and adverse cardiac events.

Main Methods:

  • Systematic literature search of four electronic databases.
  • Meta-analysis of eight studies involving 744 patients using a random-effects model.
  • Outcomes assessed included Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, TIMI myocardial blush grade (TMBG), complete ST-segment resolution, major adverse cardiac events (MACE), and major bleeding.

Main Results:

  • Delayed stenting (DS) demonstrated significantly improved TIMI grade 3 flow (OR: 5.09), TMBG (OR: 4.17), and complete ST-segment resolution (OR: 2.16) compared to immediate stenting (IS).
  • DS was associated with a reduction in major adverse cardiac events (MACE) (OR: 0.48).
  • No significant difference in major bleeding events was observed between DS and IS (OR: 1.76).

Conclusions:

  • Delayed stenting (DS) provides superior myocardial tissue reperfusion in STEMI patients with high thrombus burden.
  • DS is associated with decreased major adverse cardiac events (MACE) without an increased risk of major bleeding.
  • DS may be the preferred strategy for STEMI patients with high thrombus burden.
Abstract

Keywords:
No-reflow phenomenonRandomized controlled trialsST-segment elevation myocardial infarctionStentsThrombosis

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

77.8K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K
Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.5K