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Updated: Feb 11, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
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[Radiochemotherapy for invasive bladder cancer : An update].
1Klinik für Strahlentherapie und Onkologie, Universitätsklinikum Frankfurt, Goethe Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Deutschland. nikolaos.tselis@kgu.de.
Der Urologe. Ausg. A
|April 14, 2018
Summary
Multimodal therapy, including transurethral resection of the bladder tumor (TUR-B) and radiochemotherapy (RCT), offers a viable organ-preservation alternative to radical cystectomy for muscle-invasive bladder cancer.
Area of Science:
- Oncology
- Urology
Background:
- Radical cystectomy with pelvic lymphadenectomy is the standard treatment for muscle-invasive bladder cancer.
- Organ-preservation using multimodal therapy presents a viable alternative to radical surgery.
Purpose of the Study:
- To present the concept and outcomes of multimodal therapy for muscle-invasive bladder cancer.
- To evaluate organ-preservation treatment regimens and compare them with cystectomy.
Main Methods:
- Evaluation of retrospective cohorts and prospective studies on organ-preservation.
- Comparative meta-analyses of cystectomy versus multimodal treatment.
Main Results:
- Complete transurethral resection of the bladder tumor (TUR-B) followed by simultaneous radiochemotherapy (RCT) is recommended.
- Cisplatin-based or 5-fluorouracil/mitomycin C regimens are effective radiosensitizers.
- Complete response rates of 60-90%, 5-year survival of 40-75%, and bladder preservation in ~80% of survivors.
Conclusions:
- Multimodal therapy (TUR-B + RCT) is a viable alternative to radical cystectomy for muscle-invasive bladder cancer.
- Patients with early-stage tumors (cT2/3N0) achieving complete resection (R0) after TUR-B are ideal candidates.
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