Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Characteristics of Practical Op Amps

Characteristics of Practical Op Amps

A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...

Theoretical Foundations of Nursing Practice

Theoretical Foundations of Nursing Practice

Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...

Equivalent Circuits for Practical Transformers

Equivalent Circuits for Practical Transformers

The practical equivalent circuits of single-phase two-winding transformers exhibit significant deviations from their idealized versions due to the inherent properties of winding resistance and finite core permeability. These properties result in real and reactive power losses, affecting the transformer's performance. Understanding these deviations is crucial for designing more efficient transformers.
In a practical transformer, each winding exhibits resistance and leakage reactance. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sulfur oxidation and reduction are coupled to nitrogen fixation in the roots of the salt marsh foundation plant Spartina alterniflora.

Nature communications·2024

Same author

A diagnostic support system based on pain drawings: binary and k-disease classification of EDS, GBS, FSHD, PROMM, and a control group with Pain2D.

Orphanet journal of rare diseases·2023

Same author

[Rare diseases in the differential diagnosis of myalgia].

Der Nervenarzt·2022

Same author

[Rare diseases in the differential diagnosis of myalgia].

Schmerz (Berlin, Germany)·2022

Same author

[Pain management in rare diseases].

Schmerz (Berlin, Germany)·2020

Same author

Adrenal insufficiency is a contraindication for omalizumab therapy in mast cell activation disease: risk for serum sickness.

Naunyn-Schmiedeberg's archives of pharmacology·2020

Same journal

Der Urologe. Ausg. A·2022

Same journal

Der Urologe. Ausg. A·2022

Same journal

Der Urologe. Ausg. A·2022

Same journal

Der Urologe. Ausg. A·2022

Same journal

Der Urologe. Ausg. A·2022

Same journal

Der Urologe. Ausg. A·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 11, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

[Cannabinoid therapy in practice].

T Rasche¹, D Emmert¹, C Stieber¹

¹Zentrum für Seltene Erkrankungen (ZSEB), Universitätsklinikum Bonn, Bonn, Deutschland.

Der Urologe. Ausg. A

|April 14, 2018

Summary

This summary is machine-generated.

Cannabis-based drugs show limited evidence for widespread efficacy, with nabiximols approved only for multiple sclerosis spasticity. Further research is needed to confirm benefits for other conditions like pain and cachexia.

Keywords:

Anesthetics Cannabidiol Cannabinoid receptor Palliative care Palliative medicine

More Related Videos

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

Related Experiment Videos

Last Updated: Feb 11, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

Area of Science:

Pharmacology
Medical Science
Cannabinoid Research

Background:

Growing interest in cannabis-based drugs from both media and scientific communities.
Exploration of their mechanisms of action and therapeutic potential.

Purpose of the Study:

To review and discuss the current evidence for cannabis-based drugs.
To evaluate their applications in supportive and palliative care.

Main Methods:

A comprehensive review of recent scientific literature.
Evaluation of existing studies on cannabinoid efficacy and safety.

Main Results:

Limited evidence supports the efficacy of cannabinoids across many medical fields.
Nabiximols are approved in Germany for therapy-resistant multiple sclerosis spasticity.
Cannabinoids show potential for neuropathic pain, cancer pain, and HIV-related cachexia when used adjunctively.

Conclusions:

Current assessments of cannabinoids often rely on low-evidence studies.
More extensive research with larger participant numbers and long-term outcome evaluations is necessary.