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Updated: Feb 11, 2026
A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
Published on: May 1, 2013
Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma
Shigemitsu Horie1, Hayato Nishida1, Toshihiko Sakurai1
1Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Abstract:
Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.
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