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Small molecule KDM4s inhibitors as anti-cancer agents
Hongzhi Lin1, Qihang Li1, Qi Li1
1a Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
Abstract:
Histone demethylation is a vital process in epigenetic regulation of gene expression. A number of histone demethylases are present to control the methylated states of histone. Among these enzymes, KDM4s are one subfamily of JmjC KDMs and play important roles in both normal and cancer cells. The discovery of KDM4s inhibitors is a potential therapeutic strategy against different diseases including cancer. Here, we summarize the development of KDM4s inhibitors and some related pharmaceutical information to provide an update of recent progress in KDM4s inhibitors.
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