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Long-term visual outcomes for treatment of submacular haemorrhage secondary to polypoidal choroidal vasculopathy

Hyun Goo Kang1, Hyunseung Kang1, Suk Ho Byeon2

  • 1Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Clinical & Experimental Ophthalmology
|April 14, 2018
PubMed

Insights

Intravitreal bevacizumab (IVB) monotherapy is as effective as combination treatments for submacular haemorrhage (SMH) from polypoidal choroidal vasculopathy (PCV) long-term. This suggests IVB monotherapy may be a cost-effective strategy for managing PCV-related SMH.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Vascular Anomalies

Background:

  • Submacular haemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV) lacks a consensus on optimal management.
  • Evaluating long-term outcomes of different treatment strategies is crucial for clinical decision-making.

Purpose of the Study:

  • To compare the long-term visual outcomes of three treatment strategies for PCV with SMH.
  • Assess the efficacy and potential cost-effectiveness of different interventions.

Main Methods:

  • Retrospective case series involving 48 eyes treated between 2006 and 2016.
  • Patients received either intravitreal bevacizumab (IVB) monotherapy, IVB with pneumatic displacement (PD), or IVB with vitrectomy (TPPV).
  • Best-corrected visual acuity (BCVA) was monitored up to 24 months.

Main Results:

  • No significant differences in final BCVA at 24 months were observed between the groups (P = 0.062).
  • Sustained visual improvement (over three Snellen lines) was achieved in 31.82% of IVB monotherapy, 71.43% of IVB+PD, and 58.33% of IVB+TPPV eyes (P = 0.043).
  • SMH recurrence rates were low and not significantly different across groups.

Conclusions:

  • Intravitreal bevacizumab monotherapy demonstrates comparable long-term effectiveness to combination therapies for SMH secondary to PCV.
  • IVB monotherapy may represent a cost-effective approach for the long-term management of this condition.
Abstract

Keywords:
bevacizumabchoroidmacular degenerationneovascularizationretina

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