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Allogeneic fetal stem cell transplantation to child with psychomotor retardation – A case report

Katerina Dajić, Vesna Veličković, Predrag Djurdjević

    Srpski Arhiv Za Celokupno Lekarstvo
    |April 14, 2018
    PubMed

    Insights

    Fetal stem cell transplantation for psychomotor retardation and epilepsy is not effective and poses serious health risks. This case highlights severe complications like sepsis and pneumonia due to immune imbalance, underscoring the dangers of unproven therapies.

    Area of Science:

    • Pediatric Hematology and Oncology
    • Immunology
    • Neuroscience

    Background:

    • Autologous and allogeneic stem cell transplantation (hematopoietic stem cells) are established treatments for malignant diseases in children and adults.
    • The efficacy of fetal stem cell transplantation for neurological conditions like psychomotor retardation and epilepsy remains unproven and poorly understood.

    Observation:

    • A 9.5-year-old boy received allogeneic fetal stem cells for psychomotor retardation and epilepsy.
    • Post-transplantation, the patient developed life-threatening sepsis and severe pleuropneumonia.
    • Immune analysis revealed adequate humoral immunity but compromised cellular immunity, with a T-suppressor lymphocyte predominance.

    Findings:

    • The patient's neurological deficits (psychomotor retardation, dyslalia, epilepsy, strabismus, amblyopia) showed no improvement.
    • The immune imbalance was strongly associated with the delayed onset of severe sepsis and pleuropneumonia.
    • Fetal stem cell therapy for these unconfirmed indications resulted in severe adverse events.

    Implications:

    • Using fetal stem cells for unvalidated indications like neurological disorders poses significant risks to patients.
    • Such practices can lead to severe infections, immune dysregulation, and failure to improve the underlying condition.
    • This case underscores the critical need for evidence-based medicine and cautions against the misuse of stem cell therapies, protecting patients and healthcare systems.
    Abstract

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