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Related Concept Videos

Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
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Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

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Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
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Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Naming Skeletal Muscles01:19

Naming Skeletal Muscles

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The naming of the approximately 700 muscles in the human body is based on a set of criteria designed to provide descriptive information about each muscle, making it easier to identify and remember them.
The key factors used in naming muscles include:
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Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Related Experiment Video

Updated: Feb 11, 2026

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
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Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

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Stem Cells for Skeletal Muscle Tissue Engineering.

Molly N Pantelic1, Lisa M Larkin1,2

  • 11 Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, Michigan.

Tissue Engineering. Part B, Reviews
|April 14, 2018
PubMed
Summary
This summary is machine-generated.

Volumetric muscle loss (VML) treatments are improving with skeletal muscle tissue engineering (SMTE). Researchers are exploring alternative stem cells beyond satellite cells for more practical and effective VML therapies.

Keywords:
satellite cellskeletal muscletissue engineering

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Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
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Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Volumetric muscle loss (VML) is a severe condition impairing muscle repair, often resulting from combat injuries.
  • Current surgical treatments for VML are suboptimal, necessitating advanced therapeutic approaches.
  • Skeletal muscle tissue engineering (SMTE) offers a promising alternative to traditional grafting methods.

Purpose of the Study:

  • To review the current state of satellite cell-based SMTE for VML.
  • To explore alternative myogenic stem cells for SMTE applications.
  • To guide tissue engineers in utilizing alternative stem cells for VML treatment.

Main Methods:

  • Review of existing literature on satellite cell-based SMTE.
  • Analysis of properties and advantages of alternative stem cell sources (e.g., adipose-derived, mesenchymal, perivascular, iPSCs, ESCs).
  • Evaluation of the clinical practicality of different stem cell sources for SMTE.

Main Results:

  • Satellite cells, while native precursors, present isolation and purification challenges for clinical SMTE.
  • Alternative stem cells possess myogenic potential and offer distinct advantages for SMTE.
  • Further research is needed to detail the efficacy and practicality of alternative stem cells in SMTE.

Conclusions:

  • Alternative myogenic stem cells show promise for advancing SMTE beyond satellite cells.
  • Exploring these alternative sources is crucial for developing functional, safe, and practical VML treatments.
  • This review provides a foundation for incorporating alternative stem cells into future SMTE research for VML.