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Prevalent hepatitis B surface antigen among first-time blood donors in Gabon

Jean Marie Eko Mba1,2, Cyrille Bisseye2, Jophrette Mireille Ntsame Ndong1

  • 1Centre National de Transfusion sanguine, Libreville, Gabon.

Plos One
|April 14, 2018
PubMed

Insights

Hepatitis B virus (HBV) infection is highly endemic in Gabon, with a 7.28% seroprevalence found in blood donors. Higher rates were observed in males, adults aged 25-35, and family/replacement donors.

Area of Science:

  • Hepatology
  • Epidemiology
  • Infectious Diseases

Background:

  • Chronic Hepatitis B virus (HBV) infection is a primary cause of liver disease in Africa.
  • Limited data exists on HBV seroprevalence in the Gabonese general population.
  • Understanding HBV epidemiology is crucial for public health interventions.

Purpose of the Study:

  • To determine HBV seroprevalence in Gabonese blood donors.
  • To identify risk factors associated with HBV infection.
  • To provide epidemiological data for public health strategies.

Main Methods:

  • Screening of Hepatitis B surface antigen (HBsAg) using 4th generation ELISA kits.
  • Analysis of data from blood donors between 2009 and 2016.
  • Statistical analysis to identify risk factors including gender, age, and donation type.

Main Results:

  • Overall HBsAg seroprevalence was 7.28%.
  • Seroprevalence was significantly higher in males (OR=1.90) and the 25-35 age group (OR=1.64).
  • Family/replacement donors (FRD) showed higher seroprevalence than voluntary non-remunerated donors (VNRD).

Conclusions:

  • Gabon exhibits high endemicity of HBV infection.
  • Specific demographic groups, including males and adults aged 25-35, are at higher risk.
  • Targeted screening and prevention strategies are needed for high-risk populations.

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