Related Experiment Video

Updated: Feb 11, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.4K

[Association of OSMR gene polymorphisms with dilated cardiomyopathy in a Han Chinese population]

Xiaohui Dai1, Ying Peng, Bin Zhou

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. lrlz1989@163.com.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|April 14, 2018
PubMed

Insights

Genetic variations in the oncostatin M receptor (OSMR) gene, specifically rs2292016, are linked to the development and prognosis of dilated cardiomyopathy (DCM). The GT genotype increases DCM risk, while the GG genotype indicates a poorer outcome in patients not receiving cardiac resynchronization therapy.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Genetic Epidemiology

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Genetic factors play a crucial role in DCM pathogenesis.
  • The oncostatin M receptor (OSMR) gene is implicated in cardiovascular function.

Purpose of the Study:

  • To investigate the association between OSMR gene polymorphisms and DCM in a Han Chinese population.
  • To evaluate the impact of specific OSMR single nucleotide polymorphisms (SNPs) on DCM susceptibility and prognosis.

Main Methods:

  • Genotyping of two OSMR SNPs (rs2292016 and rs2278329) in 351 DCM patients and 418 healthy controls using TaqMan assay.
  • Clinical follow-up of 200 DCM patients for prognosis assessment.
  • Statistical analysis to determine associations with DCM development and outcomes.

Main Results:

  • The GT genotype of rs2292016 was significantly associated with an increased risk of DCM (OR=1.45, P=0.01).
  • In patients not receiving cardiac resynchronization therapy, the GG genotype of rs2292016 independently predicted a poor prognosis (OR=1.69, P=0.017).
  • No significant association was observed for rs2278329 with DCM susceptibility or prognosis.

Conclusions:

  • Polymorphisms in the OSMR gene, particularly at the rs2292016 locus, are associated with both the development and clinical outcome of dilated cardiomyopathy.
  • The rs2292016 SNP may serve as a potential genetic marker for DCM risk and prognosis.
Abstract

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.4K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.4K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
526
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
587
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
470
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K