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[A weak D type 59 case identified in the Chinese Han population]
Zhaoping Liao1, Huiying Xu, Chunhua Liu
1Department of Transfusion, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. zrtzh@zju.edu.cn.
Objective:
To study a case with weak D59 phenotype identified among ethnic Han Chinese population.
Methods:
Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members.
Results:
A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype. RHD zygosity testing confirmed that the proband had a RHD+ /RHD- genotype.
Conclusion:
A weak D59 phenotype was firstly identified in a Chinese individual.
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