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Streptococcus pneumoniae serotype distribution in Vojvodina before the introduction of pneumococcal conjugate

Vladimir Petrović, Zorica Šeguljev, Mioljub Ristić

    Srpski Arhiv Za Celokupno Lekarstvo
    |April 14, 2018
    PubMed

    Insights

    This study analyzed Streptococcus pneumoniae serotypes in Vojvodina, Serbia, before routine childhood immunization. Findings support the justification of pneumococcal conjugate vaccines, showing good coverage of circulating strains.

    Area of Science:

    • Microbiology and Immunology
    • Vaccinology
    • Public Health

    Background:

    • Streptococcus pneumoniae is a leading cause of bacterial pneumonia and meningitis.
    • Serbia introduced mandatory childhood immunization against pneumococcal diseases.

    Purpose of the Study:

    • To determine the prevalence and distribution of pneumococcal serotypes in Vojvodina, Serbia.
    • To assess the coverage of pneumococcal conjugate vaccines (PCV7, PCV10, PCV13) and the 23-valent polysaccharide pneumococcal vaccine (PPV23) based on circulating serotypes before vaccine implementation.

    Main Methods:

    • Collected 105 Streptococcus pneumoniae isolates from January 2009 to April 2016 in Vojvodina.
    • Performed serotyping in the National Reference Laboratory.
    • Analyzed serotype distribution and vaccine coverage across different age groups.

    Main Results:

    • Identified 21 different Streptococcus pneumoniae serotypes, with serotypes 3, 19F, and 14 being the most frequent.
    • PCV13 demonstrated 84.8% serotype coverage, and PPV23 covered 89.5% of all isolates.
    • In children ≤5 years, PCV7, PCV10, and PCV13 covered 72.0%, 76.0%, and 88.0% of isolates, respectively.

    Conclusions:

    • The distribution of Streptococcus pneumoniae serotypes in the population aligns well with vaccine-included serotypes.
    • The implementation of childhood immunization programs against pneumococcal diseases is justified.
    • Findings from Vojvodina are applicable to Serbia as a whole.
    Abstract

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