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A Practical Approach to Genetic Inducible Fate Mapping: A Visual Guide to Mark and Track Cells In Vivo
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Directing neuronal cell fate in vitro: Achievements and challenges

R J M Riemens1, D L A van den Hove2, M Esteller3

  • 1Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain; Institute of Human Genetics, Julius Maximilians University, Wuerzburg, Germany; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.

Progress in Neurobiology
|April 14, 2018
PubMed
Summary

Human pluripotent stem cell (PSC) technology and direct somatic cell reprogramming enable the creation of diverse human neurons in vitro. Ongoing research focuses on optimizing protocols for disease modeling, drug discovery, and regenerative medicine.

Keywords:
Brain disordersCellular reprogrammingDirected differentiationDisease modellingEpigeneticsNeuronal differentiationPluripotent stem cellsSomatic cellsTransdifferentiation

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