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Src activation decouples cell division orientation from cell geometry in mammalian cells

Xiaoyan Sun1, Hongsheng Qi2, Xiuzhen Zhang3

  • 1Institute for Regenerative Cures, University of California, Davis, CA, USA; Department of Dermatology, University of California, Davis, CA, USA; Department of Ophthalmology, University of California, Davis, CA, USA; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P.R. China.

Biomaterials
|April 14, 2018
PubMed
Summary

Src (proto-oncogene tyrosine-protein kinase) regulates cell division orientation in mammalian cells. Inhibiting Src maintains correct cell division alignment, while its activation leads to misorientation, a hallmark of cancer.

Keywords:
Cell division orientationCell geometryCell polarityMitosisSrc

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