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Human placental cells that regulate lymphocyte function.

R L Wolf1

  • 1Department of Pediatrics, Michael Reese Hospital and Medical Center, Chicago, Illinois.

Pediatric Research
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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Normal human placenta releases soluble inhibitory factor (SIF), a substance that suppresses immune cell responses. This placental SIF shares characteristics with SIF produced by lymphocytes, indicating a shared immunologic function.

Area of Science:

  • Immunology
  • Cell Biology
  • Reproductive Biology

Background:

  • Soluble inhibitory factor (SIF) is produced by T lymphocytes and blocks immune cell proliferation and antibody production.
  • SIF contains a lipid suppressor substance and is associated with suppressor cells.
  • The immunologic role of the human placenta is not fully understood.

Purpose of the Study:

  • To investigate the immunologic function of the normal human placenta.
  • To determine if the placenta releases soluble inhibitory factor (SIF).
  • To characterize placental SIF and compare it to SIF from lymphocytes.

Main Methods:

  • Giant cells were isolated from normal human placentae via collagenase digestion.
  • Cells were cultured, and conditioned medium was assayed for SIF activity.

Related Experiment Videos

  • SIF activity was measured by suppression of lymphocyte proliferation ( [3H]thymidine incorporation).
  • Thin-layer and ion exchange chromatography were used to characterize placental SIF.

    • Main Results:

    • Placental SIF significantly inhibited lymphocyte proliferation by 88% (p < 0.001).
    • Placental SIF contains lipid suppressor substance, migrating similarly to lymphocyte SIF on thin-layer chromatography.
    • Ion exchange chromatography indicated that placental SIF and lymphocyte SIF elute in the same buffer fraction.
    • Both placental and lymphocyte SIF function by inducing suppressor cells.

    Conclusions:

    • Normal human placenta releases soluble inhibitory factor (SIF) with immunosuppressive properties.
    • Placental SIF is biochemically and functionally similar to SIF derived from lymphocytes.
    • These findings suggest a role for placental SIF in modulating maternal immune responses during pregnancy.