An internet-based intervention for people with psychosis (EviBaS): study protocol for a randomized controlled trial

Area of Science:

• Psychiatry and Mental Health
• Digital Therapeutics
• Clinical Psychology

Background:

• Internet-based self-help interventions show efficacy for various mental disorders.
• Online interventions for psychotic disorders are limited, despite the high global burden of psychosis.
• Implementing cognitive-behavioral therapy (CBT) for psychosis in routine care presents challenges.

Purpose of the Study:

• To evaluate the feasibility and efficacy of a comprehensive CBT-based online self-help intervention for individuals with psychosis.
• To address the treatment gap for psychosis through accessible digital interventions.
• To assess the intervention's impact on positive psychotic symptoms.

Main Methods:

• A randomized controlled trial comparing an 8-week online intervention with a waiting list control group.
• The intervention includes modules on delusions, voice hearing, social competence, and mindfulness, with moderator support.
• Primary outcome is the change in positive psychotic symptoms; predictors of treatment effects will also be assessed.

Main Results:

• This study represents one of the first large-scale investigations of an internet-based intervention for psychosis.
• The intervention's feasibility and efficacy compared to a waiting list control group will be determined.
• Analysis will identify predictors of treatment effects.

Conclusions:

• The developed CBT-based online self-help intervention offers a potential new avenue for treating psychosis.
• This digital approach may broaden treatment options and improve accessibility for individuals with psychotic disorders.
• Further research will establish the intervention's role in routine mental healthcare.