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Updated: Feb 11, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Meningeal carcinomatosis: three case-reports

Guangyong Chen1, Long Ma1, Meiling Xu2

  • 1Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.

World Journal of Surgical Oncology
|April 15, 2018
PubMed
Abstract

Insights

Meningeal carcinomatosis (MC) diagnosis is improved with enhanced MRI, offering better detection and potentially longer survival. This imaging technique is crucial for identifying meningeal abnormalities.

Area of Science:

  • Neurology
  • Oncology
  • Radiology

Background:

  • Meningeal carcinomatosis (MC) involves diffuse tumor cell infiltration of the meninges without brain or spinal cord parenchymal mass.
  • MC can be primary or metastatic, with diagnosis historically relying on post-operative or autopsy findings.
  • Advances in imaging and cytology have increased MC case reporting.

Observation:

  • Three MC cases were confirmed using lumbar puncture and gadolinium-enhanced magnetic resonance imaging (MRI).
  • Patients presented with distinct imaging manifestations attributed to their diverse primary diseases.
  • Enhanced MRI is highly sensitive for detecting meningeal abnormalities in MC.

Findings:

  • Enhanced MRI plays a critical role in diagnosing meningeal carcinomatosis.
  • Conventional cerebrospinal fluid examinations are insufficient as some MC meninges do not enhance.
  • Diverse MR contrast agents can improve lesion conspicuity and detection rates.

Implications:

  • Enhanced MRI significantly aids in the diagnosis of meningeal carcinomatosis.
  • Improved detection rates through advanced contrast agents may enhance patient outcomes.
  • Further research into MR contrast agents could improve MC detection and patient survival.
Keywords:
Cerebrospinal abbreviation cytologyEnhanced MRIMRIMeningeal carcinomatosis

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