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Related Experiment Video

Updated: Feb 11, 2026

Autofluorescence Imaging to Evaluate Cellular Metabolism

Autofluorescence Imaging to Evaluate Cellular Metabolism

Published on: November 15, 2021

Cellular Metabolism and Aging.

¹Huffington Center on Aging, Stem Cells and Regenerative Medicine Center, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, United States.

Progress in Molecular Biology and Translational Science

|April 15, 2018

Summary

Aging involves metabolic shifts impacting cellular health and lifespan. This review explores how changes in protein quality, mitochondria, epigenetics, and nutrient-sensing pathways influence aging and longevity.

Keywords:

epigenetics mitochondria nutrient-sensing pathways proteostasis

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Autofluorescence Imaging to Evaluate Cellular Metabolism

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Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

Area of Science:

Biochemistry
Cellular Biology
Gerontology

Background:

Metabolic changes are key indicators of the aging process.
Alterations in specific metabolic pathways can influence lifespan.
Understanding these changes is crucial for addressing age-related decline.

Purpose of the Study:

To review the biochemical and homeostatic changes occurring during aging at the cellular level.
To highlight the roles of protein quality control, mitochondria, epigenetics, and nutrient-sensing pathways in aging.
To examine the interplay of these systems and their impact on cellular health.

Main Methods:

Literature review of aging research.
Analysis of cellular biochemistry and energy homeostasis.
Focus on key aging-related pathways and systems.

Main Results:

Aging alters cellular biochemistry and energy balance.
Protein quality control, mitochondria, epigenetics, and nutrient-sensing pathways are significantly affected by aging.
The interaction between these systems is critical for maintaining cellular health during aging.

Conclusions:

Metabolic alterations are central to aging.
Interventions targeting these pathways hold potential for extending lifespan and improving healthspan.
A holistic view of interconnected cellular systems is necessary for understanding aging.