Related Experiment Video
Updated: Feb 11, 2026

High Throughput Analysis of Liquid Droplet Impacts
Published on: March 6, 2020
Implementation of multicriteria decision analysis in design of experiment for dispersive liquid-liquid
Paulina Bigus1, Jacek Namieśnik1, Marek Tobiszewski1
1Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology (GUT), 11/12 G. Narutowicza St., 80-233 Gdańsk, Poland.
Abstract:
A novel and efficient approach to optimization of extraction step prior the chromatographic determination of nine chlorinated phenols is described. It is based on the combination of design of experiments and multicriteria decision analysis. Such an approach is used to optimize dispersive liquid-liquid microextraction procedure for the determination of 9 chlorophenols in water samples. Three parameters are optimized - sample volume, volume of disperser solvent and extraction solvent. Combination of the technique for order of preference by similarity to ideal solution with central composite design allows to perform multi-analyte procedure optimization. It gives information about the efficiency of the system for every experimental plan point in terms of closeness to ideal solution. The optimal conditions for extraction of chlorophenols are 76 μL of extraction solvent, 0.6 mL of dispersive solvent and 6.7 mL of water sample. The presented approach has the potential to be applied in variety of optimization systems.
Related Concept Videos
Molecular Comparison of Gases, Liquids, and Solids
Rise of Liquid in a Capillary Tube
Deriving the Speed of Sound in a Liquid
The speed of sound in fluids can be derived by considering a mechanical wave...
High-Performance Liquid Chromatography: Introduction
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Instrumentation
Distillation: Vapor–Liquid Equilibria

