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Updated: Feb 11, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Deep Brain Stimulation associated gliosis: A post-mortem study.

Vinata Vedam-Mai1, Cooper Rodgers2, Ashley Gureck2

  • 1Department of Neurosurgery, McKnight Brain Institute, University of FL, Gainesville, FL 32610-0015, United States; Department of Neurology, UF Center for Movement Disorders and Restoration, Gainesville, FL, United States.

Parkinsonism & Related Disorders
|April 15, 2018
PubMed
Summary
This summary is machine-generated.

Post-mortem analysis of deep brain stimulation (DBS) leads revealed a glial scar in most patients. The duration of DBS therapy did not significantly affect the amount of gliosis observed around the lead tip.

Keywords:
Deep brain stimulationGliosisNeuropathologyParkinson's disease

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Area of Science:

  • Neuroscience
  • Neuropathology
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) is a recognized therapy for Parkinson's disease (PD) and an emerging treatment for other neuropsychiatric disorders.
  • Limited understanding exists regarding the specific tissue and cellular responses to DBS implantation.

Purpose of the Study:

  • To investigate the post-mortem effects of DBS leads by quantifying gliosis around the distal DBS lead tip.
  • To analyze the cellular reactions to implanted DBS hardware.

Main Methods:

  • Utilized 18 post-mortem brains from the UF DBS Brain Bank repository.
  • Performed microscopic evaluation including Hematoxylin and Eosin (H&E) and glial fibrillary acidic protein (GFAP) staining.
  • Quantified gliotic collar thickness and assessed for fibrosis and microglial response.

Main Results:

  • Approximately 75% of post-mortem DBS cases showed evidence of a glial collar at the ventral lead tip.
  • Mean gliotic collar measurements were 122.5 μm (H&E) and 162.5 μm (GFAP).
  • No statistically significant correlation was found between DBS duration and the extent of gliosis.

Conclusions:

  • A glial response is a common finding around DBS lead tips in post-mortem brains.
  • The duration of DBS therapy does not appear to influence the degree of gliosis.
  • Future research should correlate gliosis with the volume of tissue activation and clinical outcomes.