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Related Concept Videos

The Aorta01:14

The Aorta

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The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
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The Arch of Aorta01:10

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The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
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Thoracic Aorta01:15

Thoracic Aorta

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Abdominal Aorta01:25

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Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Feb 11, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Imaging Insights on the Aorta in Aging.

Yoshiaki Ohyama1, Alban Redheuil1, Nadjia Kachenoura1

  • 1Departments of Cardiology/Medicine and Radiology, Johns Hopkins University, Baltimore, MD (Y.O., B.A.V., J.A.C.L.). Sorbonne Universités, UPMC University Paris 06, INSERM 1146, CNRS 7371, Laboratoire d'Imagerie Biomédicale, Paris, France (A.R., N.K.). Department of Cardiovascular Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France (A.R.). Clinical Investigation and Research Unit, Gunma University Hospital, Maebashi, Japan (Y.O.).

Circulation. Cardiovascular Imaging
|April 15, 2018
PubMed
Summary

Magnetic resonance imaging (MRI) offers a comprehensive, noninvasive method to assess aortic structure and function changes due to aging and disease. This technique aids in understanding cardiovascular health and disease progression.

Keywords:
aortacardiovascular diseasehemodynamicsmagnetic resonance imaging

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Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Gerontology

Background:

  • The aorta serves crucial conduit and cushion functions, transmitting blood and buffering pulsatile stress.
  • Aging and disease significantly alter aortic material properties, impacting hemodynamics and cardiovascular health.
  • Noninvasive imaging is vital for assessing age-related aortic structural and functional changes.

Purpose of the Study:

  • To review the pathophysiological aspects of the aorta.
  • To evaluate the role and potential of cardiovascular imaging, particularly MRI, in studying age-related aortic alterations.
  • To explore the relationship between these aortic changes and cardiovascular disease.

Main Methods:

  • Magnetic resonance imaging (MRI) enables direct measurement of aortic structural parameters (e.g., area, wall thickness) and functional measures (e.g., strain, distensibility, pulse wave velocity).
  • Advanced techniques like 4-dimensional flow MRI can elucidate age-related effects on aortic geometry and function.
  • MRI methods demonstrate excellent reproducibility for assessing therapeutic responses.

Main Results:

  • MRI allows accurate, noninvasive assessment of diverse aortic characteristics.
  • Reproducibility of MRI methods facilitates evaluation of treatment efficacy on the entire aorta.
  • Aortic flow and function assessment via MRI can be integrated into clinical cardiac MRI routines.

Conclusions:

  • Cardiovascular imaging, especially MRI, is a valuable tool for studying age-related changes in aortic structure and function.
  • Understanding these changes is crucial for assessing cardiovascular disease risk and progression.
  • Future applications of advanced MRI techniques promise deeper insights into aortic pathophysiology.